Time, Decoded.
Aging is not random.
It is biologically
systematic.
Over the past decade, scientists have identified the core cellular mechanisms that drive aging. These mechanisms are known as the 12 Hallmarks of Aging – a scientific framework that explains why our bodies gradually lose resilience over time.
The original framework identified 9 hallmarks in 2013 in a landmark paper published in Cell by Carlos López-Otín and colleagues. In 2023, the model was expanded to 12 hallmarks, reflecting advances in aging science and a deeper understanding of cellular decline.
You can read the foundational research here:
López-Otín et al., The Hallmarks of Aging, Cell (2013)
https://pubmed.ncbi.nlm.nih.gov/23746838/
López-Otín et al., Hallmarks of Aging: An Expanding Universe, Cell (2023)
https://pubmed.ncbi.nlm.nih.gov/36599349/
This framework didn’t just inspire Stact Longevity+.
It shaped it.
Proactive Longevity
The Stact Philosophy
Most conversations about aging focus on reacting to damage. Stact Longevity+ was built around a different idea: support the body so it runs at optimal function – day after day.
Your body is rebuilding itself constantly. Proteins are synthesized. Cells divide. Mitochondria generate energy. DNA is copied and maintained. The internal environment those processes operate in matters.
When energy production is strong, antioxidant defenses are robust, nutrient signaling is efficient, and gut balance is supported, cells operate in a healthier environment.
That is proactive longevity.
The 12 Hallmarks Of Aging Explained Clearly
The 12 Hallmarks of Aging
What it means: DNA damage accumulates over time.
Why it matters: DNA is your body’s instruction manual. Errors reduce cellular efficiency.
Longevity+ nutrients that support this Hallmark include:
Vitamin C, Vitamin E, Beta-Carotene (Vitamin A precursor), Glutathione, Selenium, Zinc, Copper, Polyphenol Fruit Blend.
These nutrients support antioxidant defenses that help protect cells from oxidative stress – supporting DNA integrity over time.
What it means: Protective caps on chromosomes shorten as cells divide.
Why it matters: Shortened telomeres reduce cellular resilience.
Longevity+ nutrients that support this Hallmark include:
Folate (Quatrefolic®), Vitamin B12 (methylcobalamin), Vitamin B6 (via Niacin support pathways), Magnesium, Zinc, Vitamin D3.
These nutrients support methylation and cellular replication processes associated with chromosomal stability.
What it means: Gene activity patterns shift with age.
Why it matters: How genes are expressed influences metabolism and repair.
Longevity+ nutrients that support this Hallmark include:
Folate, Vitamin B12, Niacin, Nicotinamide Riboside, Choline, Methionine, Beta-Carotene (indirect support), Magnesium.
These nutrients support methylation pathways and NAD+ metabolism involved in gene expression regulation.
What it means: The body becomes less efficient at building and recycling proteins.
Why it matters: Proteins form muscles, enzymes, and structural tissue.
Longevity+ nutrients that support this Hallmark include:
Essential Amino Acids (Leucine, Isoleucine, Valine, Lysine, Threonine, Phenylalanine, Methionine, Histidine, Tryptophan), Glycine, Proline, Creatine, Vitamin C, Magnesium.
These nutrients provide structural building blocks and cofactors required for protein turnover and tissue maintenance.
What it means: Cells respond less efficiently to nutrient signals.
Why it matters: Efficient nutrient sensing supports metabolic balance.
Longevity+ nutrients that support this Hallmark include:
Magnesium, Zinc, Niacin, Nicotinamide Riboside, MCTs, Creatine, Boron.
These nutrients support metabolic efficiency and cellular responsiveness to nutrient availability.
What it means: Cellular energy production declines.
Why it matters: Energy drives every biological process.
Longevity+ nutrients that support this Hallmark include:
Nicotinamide Riboside, Coenzyme Q10, Creatine, MCTs, Magnesium, Niacin, Vitamin B12, Taurine.
These ingredients support cellular energy production and antioxidant balance at the mitochondrial level.
What it means: Some aging cells stop dividing but remain active.
Why it matters: Accumulation of these cells can disrupt tissue balance.
Longevity+ nutrients that support this Hallmark include:
Vitamin D3, Vitamin C, Vitamin E, Glutathione, Polyphenol Fruit Blend, Selenium, Zinc.
Stact supports optimal cellular performance and antioxidant balance, helping create an internal environment less likely to favor dysfunction.
What it means: Regenerative capacity declines.
Why it matters: Recovery slows over time.
Longevity+ nutrients that support this Hallmark include:
Essential Amino Acids, Vitamin D3, Zinc, Magnesium, Boron, Vitamin K2.
These nutrients support structural and signaling processes that underpin tissue maintenance.
What it means: Cells communicate less efficiently.
Why it matters: Clear signaling supports coordinated physiology.
Longevity+ nutrients that support this Hallmark include:
Vitamin D3, Magnesium, Zinc, Phosphatidylserine, Citicoline, Polyphenol Fruit Blend, Taurine.
These nutrients support energy production and balanced cellular signaling.
What it means: Low-grade inflammation increases over time.
Why it matters: Balanced inflammatory responses support long-term vitality.
Longevity+ nutrients that support this Hallmark include:
Vitamin D3, Vitamin C, Vitamin E, Polyphenol Fruit Blend, Glutathione, Selenium, Magnesium.
These nutrients support antioxidant systems and healthy inflammatory balance.
What it means: The gut microbiome shifts away from balance.
Why it matters: Gut health influences immunity and metabolism.
Longevity+ nutrients that support this Hallmark include:
Bacillus coagulans BC99, Polyphenol Fruit Blend.
These ingredients support microbial balance and digestive resilience.
What it means: Cells become less efficient at recycling damaged components.
Why it matters: Efficient cellular cleanup supports optimal function.
Longevity+ nutrients that support this Hallmark include:
Nicotinamide Riboside, Magnesium, Taurine, Coenzyme Q10, Polyphenol Fruit Blend.
These nutrients support metabolic efficiency and mitochondrial health – foundational processes that help maintain cellular balance.
Strong Systems. Strong Cells.
Aging is the gradual drift of interconnected biological systems away from optimal function.
Stact Longevity+ was formulated to support those systems proactively – helping the body operate in a stronger internal environment day after day.
Not by forcing biology. By supporting it.
